The complexity of cellular biology. (a) A subset of the chemical
Currently available CAR T-cell therapies are customized for each individual patient. They are made by collecting T cells from the patient and re-engineering them in the laboratory to produce proteins on their surface called chimeric antigen receptors, or CARs.
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When a T cell has a CAR added to it, it is called a "CAR T cell.". CAR T cells work by floating around the body and looking for cells that carry the antigen programmed into the CAR protein, like certain cancer cells. When a CAR T cell comes in contact with an antigen on a cancer cell, it activates. Activated CAR T cells multiply and signal.
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Biography: Dr. Bradley Cairns received his B.S. (Honors) in Chemistry from Lewis and Clark College in Portland, Oregon in 1987. He conducted his graduate work at Stanford with Nobel Laureate Roger Kornberg Ph.D. on both signal transduction and chromatin remodeling, where he was the first to purify a chromatin remodeling complex (SWI/SNF complex.
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FileEndocytic pathway of animal cells showing EGF receptors
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Scientists surprised to find that amino acids, not sugar, supply most
The main biological goal of SCNT is to reverse the differentiated state of a somatic cell, for the purpose of creating blastocysts from which embryonic stem cells (ESCs) can be derived for therapeutic cloning, or for the purpose of reproductive cloning.
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CAR Tcell Therapies Allogenic the Way to Go? BioProcess
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Adaptive Immune Response Biology II
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What is Monoclonal Antibody Therapy for Cancer? DanaFarber
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